Stephen Ireland will miss the clash with Everton on Wednesday after picking up a nasty injury during the game against Hull City on Saturday.
The midfielder, who had stepped in for the injured Bojan, is likely to be out for up to three weeks.
Mark Hughes said: “Well, as you can imagine, Stephen is unavailable tomorrow and is likely to be out for two to three weeks.
“Most people have seen the picture of the injury and it won’t surprise anybody that he had to have internal stitches as well as external ones.”
Charlie Adam is likely to deputise in place of Ireland in what would be Hughes’ only change after the 1-0 win against Hull.
Captain Ryan Shawcross is likely to miss the game however there was positive news that he is back running and could be available for the fixture away at West Brom.
Hughes added: “Ryan is back in the building and that is a positive for us. He has come back in a better frame of mind and we are delighted,” Hughes added.
“He will get back out there training again next week all being well and then it will hopefully be a couple of weeks until he is available for selection again.”
Everton will be without left-back and England international Leighton Baines who has a quad injury and missed the Toffees 2-0 defeat at the Emirates against Arsenal on Sunday.
Manager Roberto Martinez said: “We tried to give Leighton a breather against Young Boys on Thursday in the Europa League so that he was fully fit for today, but unfortunately he got a knock to his left quad on Friday and was out of this squad.
“I don’t know if he is going to be available for Wednesday – I doubt it.”
Luke Garbutt played at left-back against Arsenal and Young Boys is likely to keep his place in the position as Martinez feels a ‘specialist’ is required.
Elsewhere Aiden McGeady, Christian Atsu, Steven Pienaar and Bryan Oviedo remain doubts and are unlikely to feature at the Britannia Stadium as Everton look to pull themselves clear of the relegation zone.
Mark Clattenburg is in charge of this fixture, which will be his first Stoke assignment of the season, while this will be his second match in charge of Everton after taking charge of their 2-1 win against West Ham at Goodison Park.
In all competitions this season he has shown 126 yellow cards and only three red cards in 32 matches.
Clattenburg will be assisted by Harry Lennard and Simon Beck.